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Clinical improvement in a patient with neuromyelitis optica following therapy with the anti-IL-6 receptor monoclonal antibody tocilizumab

Araki M, Aranami T, Matsuoka T, Nakamura M, Miyake S, Yamamura T.

Source: Multiple Sclerosis Center, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan.

Neuromyelitis optica (NMO) is a disabling autoimmune disease associated with an elevation of anti-aquaporin 4 (AQP4) autoantibodies. Here, we present a case with NMO who responded to monthly administration of the anti-IL-6 receptor antibody tocilizumab. The treatment rapidly reduced the elevated numbers of plasmablasts and anti-AQP4 autoantibodies in the patient. Furthermore, neuropathic pain and disability scores gradually improved. Tocilizumab may be considered as a therapeutic option for NMO.

PMID: 22782533 [PubMed – as supplied by publisher]

Mod Rheumatol. 2012 Jul 11. [Epub ahead of print]

Link: http://www.ncbi.nlm.nih.gov/pubmed/22782533

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