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Complement-dependent pathogenicity of brain-specific antibodies in cerebrospinal fluid

J Neuroimmunol. 2013 Jan 15;254(1-2):76-82. doi: 10.1016/j.jneuroim.2012.09.010. Epub 2012 Sep 29.

Asgari N, Khorooshi R, Lillevang ST, Owens T.

Source

Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsloewsvej 25, DK-5000 Odense C, Denmark; Institute of Regional Health Services Research, University of Southern Denmark, J.B. Winsloewsvej 19, DK-5000 Odense C, Denmark.

Abstract

The specificity and potential pathogenicity of autoantibodies vary between neurological diseases. It is often unclear whether their detection in cerebrospinal fluid (CSF) is a consequence or a cause of pathology. The goal was to test whether administration of brain-specific antibodies into CSF would be sufficient for pathology. Purified immunoglobulin G from a neuromyelitis optica patient was injected intrathecally with complement to naïve mice. Histopathological analysis at 7days revealed damage to the ependyma, disruption of the CSF parenchymal barrier and pathologic lesions, distant from the site of injection. In the absence of complement there was no pathology. Autoantibody and complement in CSF are thus sufficient to initiate a pathologic cascade.

Copyright © 2012 Elsevier B.V. All rights reserved.

PMID: 23031833 [PubMed – in process]

Link: http://www.ncbi.nlm.nih.gov/pubmed/23031833