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Increased memory Th17 cells in patients with neuromyelitis optica and multiple sclerosis

OBJECTIVE: To investigate the clinical relevance of memory Th17 cells in patients with neuromyelitis optica (NMO) or multiple sclerosis (MS).

PATIENTS AND METHODS: The proportion of peripheral memory Th17 cells was determined by flow cytometry. Sera IL-17A and IL-23 levels were detected by ELISA kits.

RESULTS: Memory Th17 proportion and IL-17A level were much higher in patients with NMO or MS and were related to clinical features. After high-dose intravenous methylprednisolone (IVMP) therapy, memory Th17 proportion and IL-17A and IL-23 levels were decreased.

CONCLUSIONS: Memory Th17 is related to the development and relapse of NMO and MS, and IVMP can inhibit memory Th17.

Read More: Increased memory Th17 cells in patients with neuromyelitis optica and multiple sclerosis