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Primary Sjogren’s syndrome and neuromyelitis optica

Neuromyelitis optica (NMO) is characterized by the association of optic neuritis and myelitis without any other neurological signs. In 30 % of the cases, NMO is associated with a systemic disorders. We report two cases of NMO associated with primary Sjogren’s syndrome that was diagnosed during an acute flare of NMO. The relationship between NMO and Sjogren’s syndrome has not been clearly identified. This association likely reflects the coexistence of two autoimmune disorders. The prognosis of NMO appears to be more severe in patients having coexisting Sjogren’s syndrome, which renders useful to search for this association in patients with neuromyelitis optica.

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