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OBJECTIVE: In the present study, we examined some demographic and clinical features of Turkish LDDD patients and we compared these features with Turkish conventional MS patients, on the basis of demographic, clinical and immunological features. BACKGROUND: So called limited disseminated demyelinating diseases (LDDDs) includes optic neuritis (ON), transverse myelitis (TM), optic-spinal multiple sclerosis (OSMS) and neuromyelitis optica (NMO). OSMS and NMO select the involvement of optic nerve and spinal cord more than conventional multiple sclerosis (CMS). They have different clinical and neuroimaging features and different immunogenetic backgrounds. DESIGN/METHODS: 1706 MS patients cohort were analyzed retrospectively for the study. MS patients were classified into two main subtypes: Conventional MS (CMS) and LDDD. Their medical records and OCB in CSF were analyzed retrospectively for the study. RESULTS: There was a total 76 CMS patients diagnosed according to the Poser criteria with clinically definite MS (CMS group) and 67 LDDD patients (3.7% of cohort): 20 had ON (29.8%), 24 had TM (50.7%), 21 had OSMS (31.3%) and 7 had NMO. There was a more female predominance in OSMS group than NMO patients (p=0.00). Number of relapse in NMO patients was higher in OSMS (p=0.002). Total EDSS (p=0.003), pyramidal functional system (FS) (p=0.033), sensory FS (p=0.02), bowel-bladder FS (0.001), and visual FS (p=0.018) were significantly more impaired in NMO than OSMS. OSMS group had more female predominance than CMS (p=0.017). Relapse rate was higher in OSMS (p=0.008). Total EDSS (p=0.014), pyramidal FS (p=0.02) and visual FS (p=0.039) were also higher OSMS. Immunomudulatory treatment was significantly more in patients with CMS than OSMS (p=0.003). OCBs were positive in 83% of CMS and 9.5% of OSMS. There was no OCB-positive NMO patient. CONCLUSIONS/RELEVANCE: Our results suggested that, OSMS and NMO are completely different from CMS, on the basis of clinical and immunological features Category – MS and Related Diseases – Clinical Science

Read More: The Clinical and Immunological Comparison of Limited Disseminated Demyelinating Diseases and Conventional Multiple Sclerosis