Posts tagged: mri

OBJECTIVES: Spinal cord compression may be associated with a fusiform cord lesion on T2-weighted magnetic resonance imaging (MRI) images, leading to confusion with transverse myelitis and delaying effective surgical treatment. RESULTS: We describe 5 patients referred for evaluation of suspected neuromyelitis optica in whom the final diagnosis was symptomatic cervical spinal stenosis.

We report the case of a 31-year-old woman who presented with neuromyelitis optica (NMO) associated with Sjogren syndrome and distal renal tubular acidosis. She was hospitalized because of cervical transverse myelopathy and right optic neuritis. She had been clinically diagnosed with Sjogren syndrome, with a high titer of anti-SS-A antibody (1:500) and anti-SS-B antibody (1:498)

Recently, a disease-specific antibody was found in serum from patients with neuromyelitis optica (NMO), and its target antigen was identified as aquaporin 4 (AQP4) water channel protein. There is no clinical picture of pediatric cases with anti-AQP4 antibody, except one report from North America. Here, we report the clinical features of 18 Japanese anti-AQP4 antibody -positive patients with childhood-onset of NMO

Objective: To analyse clinicoepidemiological features of neuromyelitis optica in a large cohort and to compare the differences between onset age, gender and clinical phenotypes. Methods: Antiaquaporin-4 antibody (AQP4-ab) levels were tested in 2366 serum samples of patients diagnosed as having central nervous system inflammatory demyelinating disorders by their referring physicians. AQP4-ab was measured by indirect immunofluorescence staining using human AQP4-transfected HEK 293 cells.

Background: Neuromyelitis optica (NMO) frequently begins with a monofocal episode of optic neuritis or myelitis. A concept named high-risk syndrome (HRS) for NMO has been proposed for patients with monofocal episodes and NMO-IgG antibodies. Objective: To describe HRS patients and compare them with NMO patients

A 21-year-old right-handed woman suffered cervical myelitis in 1971, followed by two episodes of bilateral optic neuritis and four relapses of thoracic or lumbar myelitis through 1998. Her initial brain MRI in 1989 revealed no abnormality, which met the MRI criteria for multiple sclerosis. In 2009, her serum anti-aquaporin-4 antibody was found to be positive, and a diagnosis of relapsing neuromyelitis optica (NMO) was made on the basis of current diagnostic criteria

OBJECTIVE: To analyze the magnetic resonance imaging (MRI) characteristics of neuromyelitis optica (NMO) in Chinese patients. METHODS: We retrospectively reviewed the MRI films of 61 patients with NMO (including 57 female and 4 male patients) admitted in our department

Introduction: Recurrent NMO is an idiopathic inflammatory demyelinating disease of the CNS that preferentially affects the optical nerve and spinal cord. Only recently some studies reported RNMO in pediatric population. Objective: describe the clinical course of pediatric patients diagnosed with RNMO

Backgrounds: The distinction between neuromyelitis optica (NMO) and multiple sclerosis (MS) has long been a debate in Asia. The most specific finding for NMO is a longitudinally extensive, central cord lesion on MRI in the setting of myelitis (LETM), which is very rare in MS. The MRI criterion for LETM (contiguous spinal cord lesion 3 or more segments in length) is crucial.

Anti-aquaporin-4 antibody (NMO-IgG) is used as a diagnostic marker for neuromyelitis optica (NMO). Although the mechanism of spinal cord lesions in NMO has been investigated, that of extensive hemispheric lesions with brain edema remains unclear.

Purpose: Paroxysmal tonic spasms (PTS) are brief, stereotypic, repetitive events of painful dystonic posturing that occur in association with multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). They are a hallmark of central nervous system demyelination and are putatively due to ion channel dysfunction on or adjacent to demyelinated axons

OBJECTIVE:To investigate the characteristics of the linear lesions and longitudinally extensive spinal cord (LESC) lesions in Chinese patients with neuromyelitis optica (NMO).