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Pathogenic T cell responses against aquaporin 4. Pohl M , Fischer MT , Mader S , Schanda K , Kitic M , Sharma R , Wimmer I , Misu T , Fujihara K , Reindl M , Lassmann H , Bradl M . Source Department of Neuroimmunology, Center for Brain Research, Medical University Vienna, Spitalgasse 4, 1090, Vienna, Austria.


Abstract Autologous peripheral hematopoietic stem cell transplantation (APHSCT) was performed to treat a patient with neuromyelitis optica. We observed that the patient achieved clinical remission after APHSCT during 12 months of follow-up. The patient improved on the expanded disability status scale neurologic assessment and the Scripps neurologic rating scale worksheet scores on follow-up examination compared with baseline.


Voiding dysfunction, either urinary incontinence or retention, can have a debilitating effect upon the individual’s daily quality of life. Patients with these conditions often face many challenges in their everyday lives and can become preoccupied with constant trips to the bathroom, fear of leaking episodes and sleepless nights.


Objective In neuromyelitis optica (NMO), the destruction of the blood-brain barrier (BBB) has been considered to be the first step of the disease process.


Since the description of the association between neuromyelitis optica (Devic’s disease) and aquaporin 4 IgG antibody (NMO-IgG), the search for this antibody has been considered a highly recommended laboratory test when centromedullary multisegmental lesions are observed by magnetic resonance imaging (MRI). Such MRI lesions have not been confined to acute NMO because other infectious and post-infectious disorders may display a similar lesional pattern. However, NMO-IgG has not been currently searched and associated with these myelitides


Background: The identification of biomarkers able to improve the differential diagnosis between multiple sclerosis (MS) and neuromyelitis optica (NMO) is challenging because of a different prognosis and response to treatment. Growing evidence indicates that brain and CSF N-acetyl aspartate (NAA) concentration is a useful marker for characterising different phases of axonal pathology in demyelinating diseases, and preliminary studies suggest that increased serum NAA levels may be a telltale sign of acute neuronal damage or defective NAA metabolism in oligodendrocytes


Objective: To characterize the neuropathologic features of neuromyelitis optica (NMO) at the medullary floor of the fourth ventricle and area postrema. Aquaporin-4 (AQP4) autoimmunity targets this region, resulting in intractable nausea associated with vomiting or hiccups in NMO.


Neuromyelitis optica (NMO, Devic’s disease), an uncommon demyelinating neuro-immunological disease, can be associated with autoimmune diseases. In SLE associated forms anti-aquaporin-4 antibody positivity can help differentiating between SLE nerve system manifestation and NMO.


Background: Macular star results from deposits of hard exsudate in Henle’s fiber layer radiating out in a starlike pattern in patients with infectious optic neuritis or neuroretinitis.


Background: Neuromyelitis Optica (NMO) serology is a powerful tool for differential diagnosis from Multiple Sclerosis (MS). This study aims to perform a post-marketing evaluation of the first indirect immunofluorescence assay (IIFA) commercially available for NMO serology


Neuromyelitis optica (NMO or Devic’s syndrome) is a rare autoimmune disease, previously considered a multiple sclerosis variant. The most important laboratory and clinical features are optic myelitis and transverse myelitis, associated with neuromyelitis optica-IgG antibody (NMO-IgG) positivity. Subsequent to this immunological test being available, different groups have described the not-so-rare comorbidity of neuromyelitis optica with other systemic autoimmune diseases, systemic lupus erythematosus with secondary anti-phospholipid syndrome (APS) in particular.


OBJECTIVE: To evaluate the retinal nerve fiber layer (RNFL) thickness and macular volume in neuromyelitis optica (NMO) spectrum patients using optical coherence tomography (OCT). BACKGROUND: OCT can quantify damage to retinal ganglion cell axons and can identify abnormalities in multiple sclerosis and optic neuritis (ON) eyes.


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