Anti-MOG antibodies in adult patients with de… [J Neuroimmunol. 2014] – PubMed – NCBI.
Anti-MOG antibodies in adult patients with demyelinating disorders of the central nervous system.
Author information
- 1Multiple Sclerosis Center, Utano National Hospital, 8 Ondoyama-machi, Ukyo-ku, Kyoto, 616-8255, Japan. Electronic address: tanaka@unh.hosp.go.jp.
- 2Department of Neurology, Kanazawa Medical University, Uchinada, Ishikawa, 920-0265, Japan.
Abstract
The myelin oligodendrocyte glycoprotein (MOG) is considered as a candidate marker of demyelinating disorders of the central nervous system. Here, sera samples from 48 consecutive Japanese patients with myelitis or optic neuritis (ON), but negative for anti-aquaporin (AQP) 4 antibodies (Abs), and 14 anti-AQP4 Ab-positive patients were tested for anti-MOG Abs using a cell-based immunofluorescence assay with full-length human MOG cDNA. Anti-MOG Abs were detected in four male patients with myelitis or ON. Oveall, 13 neuromyelitis optica-seronegative and all anti-AQP4 Ab-positive patients were negative for anti-MOG Abs. Hence, these findings warrant further examinations in large cohort series.
Copyright © 2014. Published by Elsevier B.V.