Diagnosis
Diagnosis
- 1. Advanced from the 2006 NMO Diagnostic Criteria
- 2. Authored by the International Panel on Neuromyelitis Optica Diagnosis (IPND)
- 3. Sponsored by The Guthy – Jackson Charitable Foundation


What are diagnostic criteria?
Who uses diagnostic criteria and how?
Who developed the new diagnostic criteria, how long did it take, and what was the process?
Describe the process by which these new criteria will be evaluated / validated in the clinic.
Why did the diagnostic criteria from 2006 need to be updated?
Summarize the current understanding of the difference between NMO and NMOSD and how their diagnostic criteria differ.
Do the 2015 criteria set a higher standard for diagnosing NMO or NMOSD around the world?
As a result of these new criteria, do you think the incidence / prevalence of NMO around the world will increase, decrease, or stay the same?
Is the official term for Neuromyelitis Optica (NMO) now Neuromyelitis Optica Spectrum Disorder (NMOSD)? If so, why?
Many people still refer to NMO as “Devic’s Disease.” Should we stop using the term “Devic’s Disease” and only use NMO or NMOSD? If so, why?
How will these new criteria impact current and future NMO patients?
How are the new diagnostic criteria most likely to benefit patients (e.g. more rapid diagnoses, more accurate diagnoses, etc.)?
How might the new diagnostic criteria impact NMOSD clinical trials or clinical studies?
ARUP Laboratories
Assay Method: ELISA** Detects anti-AQP4 antibody
Test Code: 2003036
Turn-Around Time: 1 – 8 days
Estimated Cost: Refer to hospital or doctor
www.aruplab.com
(800) 522-2787
Athena Diagnostics, Inc.
Assay Method: ELISA** Detects anti-AQP4 antibody
Test Code: 193
Turn-Around Time: 5 – 7 days
Estimated Cost: $840 – Insurance; $560 – Hospital or reference laboratory
www.athenadiagnostics.com
(800) 394-4493
BioReference Laboratories
Assay Method: Outsourced to ARUP
Test Code: 6371
Turn-Around Time: 10 business days from date of arrival
Estimated Cost: 395
www.bioreference.com
(800) 522-2787
GenPath Diagnostics
Assay Method: Outsourced to ARUP
Test Code: 6371-9
Turn-Around Time: 10 business days from date of arrival
Estimated Cost: 395
www.genpathdiagnostics.com
(800) 633-4522
Kaiser Permanente
Assay Method: Outsourced to Quest Diagnostics
Test Code: Members must inquire
Turn-Around Time: Members must inquire
Estimated Cost: Members must inquire
www.kaiserpermanente.org
(800) 464-4000
LabCorp
Assay Method: ELISA** Detects anti-AQP4 antibody
Test Code: 4210
Turn-Around Time: 3 – 4 days
Estimated Cost: 764
www.labcorp.com/wps/portal
(800) 859-6046
Mayo Clinic
Assay Method: Cell binding Assay (CBA) / Detects IgG Specific for AQP4 by Fluorescence-Activated Cell Sorting (FACS)
Test Codes:
NMOFS: Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (FACS) Assay, Serum
NMOFC: Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (FACS) Assay, Spinal Fluid
Turn-Around Time: 4 – 7 days
Estimated Cost: Based on client pricing. Institutional billing only
www.mayoclinic.org
(800) 533-1710
Mayo Clinic
Assay Method: Myelin Oligodendrocyte Glycoprotein (MOG-IgG1) Fluorescence-Activated Cell Sorting (FACS) Assay, Serum
Test Codes:
86255
Turn-Around Time: 5 – 8 days
Estimated Cost: Based on client pricing. Institutional billing only
www.mayoclinic.org
(800) 533-1710
Mayo Clinic
Assay Method: Cell binding Assay (CBA) / Detects IgG Specific for AQP4 by Fluorescence-Activated Cell Sorting (FACS)
Test Codes:
86255 X2
Turn-Around Time: 7 – 10 days
Estimated Cost: Based on client pricing. Institutional billing only
www.mayoclinic.org
(800) 533-1710
Quest Diagnostics
Assay Method: ELISA** Detects anti-AQP4 antibody
Test Code: 90382
Turn-Around Time: 7 – 14 days
Estimated Cost: 560
www.questdiagnostics.com
(877) 291-7521