Special Projects & Programs
Special Projects & Programs
CIRCLES stands for the Collaborative International Research in Clinical and Longitudinal Experience in NMO Studies. The purpose of the CIRCLES study is to create a biorepository containing longitudinally-collected data and bio samples from subjects with NMO and control subjects. The data and bio samples will be available to researchers to better understand NMO pathogenesis, clinical course, and impact of therapy. Results of these studies may identify the etiology and risk factors, biomarkers for disease progression, and treatment outcomes to guide development of novel therapies. Findings may also facilitate future research and clinical trials to investigate specific hypotheses related to NMO and to improve the lives of individuals suffering from NMO.
- Enroll volunteer NMO patients and controls into the CIRCLES study to collect biosamples and/or associated clinical information donors.
- Facilitate prospective longitudinal observational studies designed to improve understanding of etiology, pathogenesis & biomarkers of NMO.
- Support industry efforts to develop improved therapeutic agents and strategies that benefit patients with NMO.
- Expand the GJCF Biorepository in the United States and Canada
- Promote consensus-based collaboration
- Enable multiple investigation sites
- Facilitate clinical studies and accelerate industry-sponsored clinical trials

