Background: Longitudinally extensive transverse myelitis (LETM) is defined clinically by acute transverse myelitis (ATM) and radiologically by extensive spinal cord (SC) lesions spanning three or more vertebral segments on Magnetic Ressonance Image (MRI). Even that LETM carries a considerable diagnostic challenge, has been regarded as a spectrum of Neuromyelitis optica (NMO). The seropositivity for NMO IgG, a specific biomarker of NMO, is variable in LETM patients around the world and reach 30-35% in brazilian series. LETM also is related to Neuroschistossomiasis (NS), central nervous system presentation of infection caused by a Schistossoma sp, a trematode parasite, which prevalence is around 200 million people worldwide. Definite diagnosis of NS(DNS) is based in anatomo-pathological confirmation, what is not always possible in SC presentation of NS. Probable NS (PrNS) or Possible NS (PoNS) in patients with ATM requires the presence of positive epidemiology, serologic confirmation, stool examitation, and exclusion of other causes of myelopathy. NMO IgG status and his prognostic value in LETM diagnosed as NS has not been studied. Methods: We evaluated 14 consecutive patients admitted with LETM, fulfilled diagnostic criteria to DNS(1), PrNS (9) or PoNS (4). Exclusion criteria was: systemic disase associated with LETM. All patients were tested to NMOIgG status. Patients were evaluated prospectively for developing of ON or recurrence of LETM. Results: Seven men, 11 afro-brazilian were evaluated. Median age was 30.9 (range 17-51). Median time of follow-up was 2.5 years (range 0.5 – 6). MRI showed thoracic lesion (5), thoraco-lombar (6) and entire SC lesion (2). All patients were negative for NMO IgG. 8 patients experienced recurrent LETM and one developed optic neuritis, fulfilling Wingershuk’s criteria for NMO. Conclusion: NMO-IgG is negative in this sample of Brazillian patients with LETM and presumptive diagnosis of NS. The negative status of NMO-IgG does not exclude development of recurrent LETM or NMO in this series.
MENUMENU
- About NMO
-
-
- NMO FAQsAnswers to some of the most frequently asked questions about NMO, featuring video interviews with leading scientists.
- NMO & Multiple Sclerosis: Did You Know?MS and NMO are treated in different ways and early detection and treatment help ensure best outcomes.
- DiagnosisThe release of new diagnostic criteria for NMO by the International Panel for Neuromyelitis Optica Diagnosis (IPND).
- Recommended ReadingSuggested resources to read from past NMO Patient Day conferences.
-
- Approved TherapeuticsAfter more than 100 years with no approved treatment, today there are three approved therapeutics for NMOSD.
- Clinical Trials in NMOFind access to information, FAQs, and video resources about ongoing clinical trials in Neuromyelitis Optica Spectrum Disorder.
- ResearchBrowse through the results of over $70 million donated to basic and clinical research to solve neuromyelitis optica.
- NMOSD and COVID-19With information changing on a daily basis, we are reaching out to the NMOSD community to aid in your navigation of the many questions at hand.
-
- About Us
-
-
- Foundation EventsCalendar of past and upcoming foundation events, including NMO Roundtable Conference and NMO Patient Days.
- Special ProjectsLearn more about special projects including the ICC, IPND, and the CIRCLES Biorepository.
- CIRCLESCIRCLES is a clinical research study that focuses on better understanding and enabling cures for NMO.
- Industry CouncilThe Guthy-Jackson Charitable Foundation invites all members of industry to join our industry council.
-
- International Clinical ConsortiumThe ICC consists of thought leaders from over 25 countries performing translational research and medicine focused on NMO.
- Medical Advisors and ConsultantsThe medical advisors and consultants to The Guthy-Jackson Charitable Foundation include experts from UCLA, Johns Hopkins, and more.
- PressStay up to date with featured press regarding NMO and The Guthy-Jackson Charitable Foundation.
-
- New to NMO
- Breakthroughs
-
-
- Predict | Clinical BiomarkersThe exciting science of biomarkers and big data analysis is enabling GJCF and its research partners to predict risks, relapses and personalized therapy.
- Protect | Against RelapsesApproved medicines offer a best chance to minimize relapse risks. Now GJCF is driving new treatments to stop relapses in their tracks if they do occur.
-
- Pioneer | Curative TherapiesApproved therapies are a great first step toward preventing relapses. GJCF is now pioneering bold new approaches to cure NMOSD once and for all.
- Promote | Advocacy for AllPatients, caregivers and loved ones are best served with credible information and healthcare access. GJCF promotes wellness via education and advocacy.
-
- Advocacy
-
-
- EventsNMO events are happening all around the world. Browse our listing of advocacy events, educational seminars, and more. Or post your own!
- Patient Advocacy CouncilThe NMO Patient Advocacy Council provides educational resources, extends awareness to urban and rural communities, and connects patients, caregivers, and families in the NMO community.
- NMOStoriesNMOStories exists to provide everyone with a voice, every stakeholder for NMO from patients and caregivers to clinicians and nurses.
-
- Support GroupsNo matter where you are on your NMO journey or how NMO affects your life, support groups aim to offer a sense of comfort and community.
- ContactContact The Guthy-Jackson Charitable Foundation with questions about NMO, advocacy, clinical trials, support, donations, and more.
- My AccountLog in to post events, create donation pages, and get involved in the NMO community.
-
- Research
- Resources
-
-
- 10 Steps Forward10 Steps Forward that may be useful for those newly diagnosed with NMOSD or MOGAD
- NMO Patient Resource GuideOur full-text NMO Patient Resource Guide offers help and information to those who have been affected by NMO.
- VideosExplore our massive library of videos, examining everything from patient care, research, and the work of the foundation.
- Tools for DownloadDownload resources including the NMO Patient Guide, NMO/MS Brochure, Fact Sheets, and more.
-
- Webinars and Breakout SessionsWatch webinars and breakout sessions from the foundation along with our industry and nonprofit partners in the rare disease community.
- Spectrum LibraryBrowse over 1000 research publications related to neuromyelitis optica, including some of the groundbreaking research sponsored by the foundation.
- Connect the DocsExplore our map with locations of over 350 international clinicians who are experts in diagnosing and treating NMO.
- SearchSearch our website for pages, groups, resources, articles, videos, and more.
-
- Patient Stories
- Donate