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Recurrent optic neuritis and neuromyelitis optica-IgG following first and second human papillomavirus vaccinations.

Publication Date  March 2016

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Chang H1, Lee HL1, Yeo M1, Kim JS1, Shin DI1, Lee SS1, Lee SH2.

Clin Neurol Neurosurg. 2016 May;144:126-8. doi: 10.1016/j.clineuro.2016.03.023. Epub 2016 Mar 29.

Abstract

Human papillomavirus (HPV) vaccine is widely used to prevent cervical cancer caused by certain types of HPV in girls and young women. Demyelinating disorders within months following HPV innoculation have been reported, but the causal link between HPV vaccination and the onset of demyelinating disorders have not been certain. We report a case of neuromyelitis optica spectrum disorder (NMOSD) that was noteworthy because optic neuritis (ON) occurred in a very close temporal association with both the first and second HPV vaccinations, which might suggest an association between HPV vaccination and the development of NMO-IgG and recurrent ON. This emphasizes the necessity for continuing surveillance for adverse events after HPV vaccination.

Copyright © 2016 Elsevier B.V. All rights reserved.

KEYWORDS:

Autoimmune demyelinating disease; Human papillomavirus vaccine; Neuromyelitis optica; Optic neuritis

PMID:
27046292
DOI:
10.1016/j.clineuro.2016.03.023