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Research

About
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Funding Approach
The Guthy-Jackson Charitable Foundation (GJCF) is committed to enhancing the scientific and clinical knowledge base by supporting innovative research to accelerate solutions for NMOSD. Funding priorities are those that advance understanding of the pathophysiology and immunology of this disease in a manner that enables translation to clinical benefit and betterment of the NMOSD patient community. Researchers funded by GJCF are required to share research findings promptly and participate in collaborative initiatives via the GJCF International Clinical Consortium for NMOSD and other GJCF programs. To this end, regular progress reports and attendance at the annual GJCF International NMOSD conference to share insights and strategies for new ways to study and ultimately solve NMOSD are terms of research funding agreements.

Types of Grants Funded
The GJCF prioritizes leading-edge research focused on state-of-the art approaches to prevent, understand, safely and effectively treat, and ultimately cure NMOSD.
  1. Eureka Grant. A Eureka grant aims to uncover a fundamentally new concept in NMOSD. A Eureka grant may be hypothesis generating, proof-of-concept establishing, pilot study, or equivalent. Eureka grants are sharply focused on a priority unmet need or question, and may be high risk.
    Maximum Funding: Up to $50,000 U.S.
    Maximum Duration: Up to 1 year

Funding Requirements
All GJCF funded research grants require: a) a clear pathway for NMOSD patient benefit; b) specific milestones to be accomplished in each period of the project; c) a data sharing plan; and d) a specific plan to obtain follow-on research funding beyond the GJCF (e.g. NIH or equivalent agency or commercial funding). Ongoing funding of all grant types is dependent on documented progress/milestones in the prior review period, typically every quarter or 6 months in frequency.

Funding Intervals
The GJCF funds projects using a tranche model, with ongoing funding contingent on evidence-based achievement of milestones specified in the prior project period.

Indirect Cost Rate
In keeping with appropriate practices of small, non-profit, research-based foundations, the GJCF considers up to a 10% indirect cost rate when research is exclusively conducted at academic or non-profit institutions.

Cost Sharing
The GJCF encourages applications in which cost sharing with other sources is integral. Sources for cost sharing may include the NIH or equivalent agencies, other disease-focused organizations (e.g. NMSS), commercial interests and other appropriate funding entities.

Funding Eligibility
The GJCF is a non-profit foundation acting independently of any medical, academic or government institution. All consideration and decisions regarding funding eligibility are at the sole discretion of the foundation.

Application Process
Letters of Intent (LOI) regarding interest in funding consideration are welcomed, with decisions based solely on the foundation discretion. Focused on solving NMOSD, an LOI of up to 2 pages should succinctly state the unmet need or unanswered question, detail innovative concepts, methods or reagents, identify a PI and research team members, define research milestones and timeline, and specify a projected budget. Submissions are subject to review by the GJCF scientific advisory team and eligibility requirements (as above). GJCF representatives may request additional information regarding LOI content. Formal research applications are allowed upon approval by GJCF. Send LOI to info@guthyjacksonfoundation.org.
Funded Researchers
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  • Vijay Kuchroo, DVM, PhD
    Vijay Kuchroo, DVM, PhD
  • Vanda Lennon, MD, PhD
    Vanda Lennon, MD, PhD
  • Thomas Tedder, PhD
    Thomas Tedder, PhD
  • Tanuja Chitnis, MD
    Tanuja Chitnis, MD
  • Stan Nelson, MD
    Stan Nelson, MD
  • Sean Pittock, MD
    Sean Pittock, MD
  • Scott Zamvil, MD, PhD
    Scott Zamvil, MD, PhD
  • Roberto Baccala, PhD
    Roberto Baccala, PhD
  • Robert Stroud, PhD
    Robert Stroud, PhD
  • Richard Ransohoff, MD
    Richard Ransohoff, MD
  • Michael Levy, MD, PhD
    Michael Levy, MD, PhD
  • May Han, MD
    May Han, MD
  • Marios Papadopoulos, MD
    Marios Papadopoulos, MD
  • Lawrence Steinman, MD
    Lawrence Steinman, MD
  • Lawrence Cook, PhD
    Lawrence Cook, PhD
  • Kevin O’Connor, PhD
    Kevin O’Connor, PhD
  • John Rose, MD
    John Rose, MD
  • Jeffrey Bennett, MD, PhD
    Jeffrey Bennett, MD, PhD
  • Jacqueline Palace, MD
    Jacqueline Palace, MD
  • Ilya Kister, MD
    Ilya Kister, MD
  • Ilana Katz Sand, MD
    Ilana Katz Sand, MD
  • Hollie Schmidt
    Hollie Schmidt
  • Gareth John, PhD
    Gareth John, PhD
  • Friedemann Paul, MD
    Friedemann Paul, MD
  • Eric Klawiter, MD
    Eric Klawiter, MD
  • Dean Wingerchuk, MD
    Dean Wingerchuk, MD
  • Claudia Lucchinetti, MD
    Claudia Lucchinetti, MD
  • Brian Weinshenker, MD
    Brian Weinshenker, MD
  • Benjamin Greenberg, MD
    Benjamin Greenberg, MD
  • Anthony Traboulsee, MD
    Anthony Traboulsee, MD
  • Alan Verkman, MD, PhD
    Alan Verkman, MD, PhD
Institutions
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  • Accelerated Cure Project
    Accelerated Cure Project
  • Charité University
    Charité University
  • Cleveland Clinic
    Cleveland Clinic
  • Duke University
    Duke University
  • Harvard Brigham and Women's Hospital
    Harvard Brigham and Women's Hospital
  • Johns Hopkins
    Johns Hopkins
  • Massachusetts General Hospital
    Massachusetts General Hospital
  • Mayo Clinic
    Mayo Clinic
  • Mount Sinai
    Mount Sinai
  • New York University
    New York University
  • Oxford University
    Oxford University
  • St. George's, University of London
    St. George's, University of London
  • Stanford
    Stanford
  • The Scripps Research Institute
    The Scripps Research Institute
  • University of California, Los Angeles
    University of California, Los Angeles
  • University of California, San Francisco
    University of California, San Francisco
  • University of Colorado, Denver
    University of Colorado, Denver
  • University of Utah
    University of Utah
  • UT Southwestern
    UT Southwestern
  • Yale University
    Yale University