mail2

Spectrum Library

Central nervous system aquaporin-4 autoimmunity p… [Mult Scler. 2012] – PubMed – NCBI

Mult Scler. 2012 Jul 3. [Epub ahead of print]

Central nervous system aquaporin-4 autoimmunity presenting with an isolated cerebral abnormality.

Kim SH, Kim W, Kook MC, Hong EK, Kim HJ.

Source

Department of Neurology, Research Institute and Hospital of National Cancer Center, Korea.

Abstract

Advances in the understanding of central nervous system aquarporin-4 autoimmunity have promoted the recognition of diverse clinical presentations beyond the traditional view of neuromyelitis optica. We describe a patient who developed hemiparesis caused by an extensive cerebral lesion as an initial manifestation of central nervous system aquarporin-4 autoimmunity. Although the patient had no history of optic neuritis or myelitis, not only was serum anti-aquarporin-4 antibody positive, but an imaging, treatment response and histopathological features also revealed characteristic findings suggestive of central nervous system aquarporin-4 autoimmunity. The present case highlights the importance of a comprehensive evaluation for anti-aquarporin-4 antibody even in patients presenting with isolated cerebral lesions.

PMID: 22760103 [PubMed – as supplied by publisher]

Read More: Central nervous system aquaporin-4 autoimmunity p… [Mult Scler. 2012] – PubMed – NCBI