Anti-aquaporin-4 antibody in Chinese patients with central nervous system inflammatory demyelinating disorders.
Long Y, Qiu W, Hu X, Peng F, Lu Z, Wang Y, Yang Y.
Source
Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, People’s Republic of China; Department of Neurology, Clinical College, The First Affiliated Hospital of Guangdong Pharmaceutical University, 19 Nonglinxia Road, Guangzhou 510080, Guangdong Province, People’s Republic of China.
Abstract
OBJECTIVE:
To determine seroprevalence of aquaporin-4 (AQP4) antibody in Chinese patients with central nervous system (CNS) inflammatory demyelinating disorders.
METHODS:
AQP4 antibody was detected by anti-AQP4 antibody assay. We measured seroprevalence in 200 patients with neuromyelitis optica (NMO, n=44), multiple sclerosis (MS, n=46), transverse myelitis (TM, n=44), optic neuritis (ON, n=13), acute disseminated encephalomyelitis (ADEM, n=2), and other neurological diseases (OND, n=51).
RESULTS:
AQP4 antibody seropositivity was 88.6% in patients with NMO, 4.3% in patients with MS, 30.8% in patients with ON and 51.7% in patients with LETM (longitudinally extensive TM). No patients with acute partial TM, ADEM, OND were positive for AQP4 antibody. Sensitivity of the test was 88.6% (95% CI 80-95) in patients with NMO. Specificity is 97.9% (95% CI 95.1-100) in 46 MS patients, with 51 OND patients as the control group. If the patients with recurrent ON, LETM were considered high risk for NMO (n=37) and the remaining patients (n=119) were considered controls, the sensitivity of this assay would be 48.6% (95% CI 33.4-64.1) and the specificity 97.5% (95% CI 94.7-100).
CONCLUSION:
This study confirms that AQP4 antibody is a sensitive and specific biomarker for discrimination between NMO and other CNS autoimmune diseases.
Copyright © 2012. Published by Elsevier B.V.
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