J Neuroimmunol. 2016 Apr 15;293:100-4. doi: 10.1016/j.jneuroim.2016.03.004. Epub 2016 Mar 4.
Zhang DQ, Jia K, Wang R, Li T, Zhao N, Yang LN, Yang L.
The interleukin 12 (IL-12) family plays important roles in autoimmune diseases. To explore the roles of the IL-12 family members IL-27 and IL-35 in the pathogenesis of neuromyelitis optica spectrum disorders (NMOSD), we determined their serum and cerebral spinal fluid levels and assessed potential correlations with clinical characteristics. Serum IL-27 levels were negatively correlated with disease severity and spinal cord lesion length, while serum IL-35 levels were negatively correlated with disease severity and annual relapse rate. Thus, IL-27 and IL-35 may be important biomarkers of NMOSD severity and these molecules might represent potential therapeutic cytokines for treating NMOSD.
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