We identified the autoantibody against phosphoglycerate mutase 1 (PGAM1), which is a glycolytic enzyme, in sera from multiple sclerosis (MS) patients by proteomics-based analysis. We further searched this autoantibody in sera from patients with other neurological diseases. The prevalence of the anti-PGAM1 antibody is much higher in patients with MS and neuromyelitis optica (NMO) than in those with other neurological diseases and in healthy controls. It was reported that the anti-PGAM1 antibody is frequently detected in patients with autoimmune hepatitis (AIH). Results of our study suggest that the anti-PGAM1 antibody is not only a marker of AIH but also a nonspecific marker of central nervous system autoimmune diseases.
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- NMO FAQsAnswers to some of the most frequently asked questions about NMO, featuring video interviews with leading scientists.
- NMO & Multiple Sclerosis: Did You Know?MS and NMO are treated in different ways and early detection and treatment help ensure best outcomes.
- DiagnosisThe release of new diagnostic criteria for NMO by the International Panel for Neuromyelitis Optica Diagnosis (IPND).
- Recommended ReadingSuggested resources to read from past NMO Patient Day conferences.
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- Approved TherapeuticsAfter more than 100 years with no approved treatment, today there are three approved therapeutics for NMOSD.
- Clinical Trials in NMOFind access to information, FAQs, and video resources about ongoing clinical trials in Neuromyelitis Optica Spectrum Disorder.
- ResearchBrowse through the results of over $70 million donated to basic and clinical research to solve neuromyelitis optica.
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- Foundation EventsCalendar of past and upcoming foundation events, including NMO Roundtable Conference and NMO Patient Days.
- Special ProjectsLearn more about special projects including the ICC, IPND, and the CIRCLES Biorepository.
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- International Clinical ConsortiumThe ICC consists of thought leaders from over 25 countries performing translational research and medicine focused on NMO.
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- Predict | Clinical BiomarkersThe exciting science of biomarkers and big data analysis is enabling GJCF and its research partners to predict risks, relapses and personalized therapy.
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- Pioneer | Curative TherapiesApproved therapies are a great first step toward preventing relapses. GJCF is now pioneering bold new approaches to cure NMOSD once and for all.
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- EventsNMO events are happening all around the world. Browse our listing of advocacy events, educational seminars, and more. Or post your own!
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- 10 Steps Forward10 Steps Forward that may be useful for those newly diagnosed with NMOSD or MOGAD
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- Webinars and Breakout SessionsWatch webinars and breakout sessions from the foundation along with our industry and nonprofit partners in the rare disease community.
- Spectrum LibraryBrowse over 1000 research publications related to neuromyelitis optica, including some of the groundbreaking research sponsored by the foundation.
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