Bukhari W, Prain KM, Waters P, et al Incidence and prevalence of NMOSD in Australia and New Zealand J Neurol Neurosurg Psychiatry Published Online First: 26 May 2017. doi: 10.1136/jnnp-2016-314839
Wajih Bukhari1, Kerri M Prain2, Patrick Waters3, Mark Woodhall3, Cullen M O’Gorman1, Laura Clarke1, Roger A Silvestrini4, Christine S Bundell5, David Abernethy6, Sandeep Bhuta1, Stefan Blum7, Mike Boggild8, Karyn Boundy9, Bruce J Brew10, Matthew Brown11, Wallace J Brownlee12, Helmut Butzkueven13, William M Carroll14, Celia Chen15, Alan Coulthard16,17, Russell C Dale18, Chandi Das19, Keith Dear20, Marzena J Fabis-Pedrini21, David Fulcher22, David Gillis16, Simon Hawke22, Robert Heard23, Andrew P D Henderson24, Saman Heshmat1, Suzanne Hodgkinson25,26, Sofia Jimenez-Sanchez1, Trevor Killpatrick27, John King27, Christopher Kneebone9, Andrew J Kornberg28, Jeannette Lechner-Scott29, Ming-Wei Lin22, Christpher Lynch30, Richard Macdonell31, Deborah F Mason32, Pamela A McCombe33, Michael P Pender16, Jennifer A Pereira30, John D Pollard34, Stephen W Reddel34, Cameron Shaw35, Judith Spies22, James Stankovich36, Ian Sutton10, Steve Vucic24, Michael Walsh16, Richard C Wong16, Eppie M Yiu37, Michael H Barnett34, Allan G Kermode21, Mark P Marriott13, John D E Parratt38, Mark Slee39, Bruce V Taylor36, Ernest Willoughby40, Robert J Wilson2, Angela Vincent3, Simon A Broadley1,41
Abstract
Objectives We have undertaken a clinic-based survey of neuromyelitis optica spectrum disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence across the region and in populations of differing ancestry.
Background NMOSD is a recently defined demyelinating disease of the central nervous system (CNS). The incidence and prevalence of NMOSD in Australia and New Zealand has not been established.
Methods Centres managing patients with demyelinating disease of the CNS across Australia and New Zealand reported patients with clinical and laboratory features that were suspicious for NMOSD. Testing for aquaporin 4 antibodies was undertaken in all suspected cases. From this group, cases were identified who fulfilled the 2015 Wingerchuk diagnostic criteria for NMOSD. A capture–recapture methodology was used to estimate incidence and prevalence, based on additional laboratory identified cases.
Results NMOSD was confirmed in 81/170 (48%) cases referred. Capture–recapture analysis gave an adjusted incidence estimate of 0.37 (95% CI 0.35 to 0.39) per million per year and a prevalence estimate for NMOSD of 0.70 (95% CI 0.61 to 0.78) per 100 000. NMOSD was three times more common in the Asian population (1.57 (95% CI 1.15 to 1.98) per 100 000) compared with the remainder of the population (0.57 (95% CI 0.50 to 0.65) per 100 000). The latitudinal gradient evident in multiple sclerosis was not seen in NMOSD.
Conclusions NMOSD incidence and prevalence in Australia and New Zealand are comparable with figures from other populations of largely European ancestry. We found NMOSD to be more common in the population with Asian ancestry.