J Clin Immunol. 2013 Apr;33(3):666-70. doi: 10.1007/s10875-012-9837-2. Epub 2012 Nov 21.
Wang H, Wang K, Wang C, Xu F, Qiu W, Hu X.
Source
Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
Abstract
PURPOSE:
Neuromyelitis optica (NMO) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). The pathogenesis of NMO remains unclear. IL-32 is emerging as a critical molecule in the pathophysiology of immune-mediated chronic inflammatory diseases. Whether IL-32 levels are elevated in NMO patients is unclear. We aimed to determine whether IL-32 levels are elevated in NMO patients and explore its relationship with IL-6, IL-17, and Expanded Disability Status Scale (EDSS) scores.
METHODS:
Plasma IL-32α, IL-6 and IL-17A were measured by enzyme-linked immunosorbent assay in NMO (n = 26), MS (n = 23) and 22 healthy controls.
RESULTS:
We found IL-32α levels were higher in NMO patients compared with MS (p = 0.020) and healthy controls (p = 0.00001). IL-32α levels wereincreased in MS patients compared with controls (p = 0.009). IL-32α positively correlated with IL-6 and IL-17A levels and EDSS scores in NMO patients.
CONCLUSIONS:
In summary, plasma IL-32α levels are associated with inflammatory responses in NMO patients.
PMID: 23180362 [PubMed – in process]