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Relapsing optic neuritis and isolated transverse myelitis are the predominant clinical phenotypes for patients with antibodies to myelin oligodendrocyte glycoprotein in India

Multiple Sclerosis Journal 2: 1 5 DOI: 10.1177/ 2055217316675634

Lekha Pandit, Douglas Kazutoshi Sato, Sharik Mustafa, Toshiyuki Takahashi, Anitha D’Cunha, Chaithra Malli, Akshatha Sudhir and Kazuo Fujihara


Background: Clinical phenotypes of patients with antibodies to myelin oligodendrocyte glycoprotein (anti-MOGþ) are unknown in India.

Objectives: Retrospectively to characterise anti-MOGþ patients with inflammatory central nervous system disorders in India.

Method: A total of 87 patients with non-multiple sclerosis demyelinating disorders (excluding acute disseminated encephalomyelitis) who were seronegative for anti-aquaporin 4 antibody were retro- spectively analysed using a cell-based assay for anti-MOGþ status.

Results: Twenty-five patients were anti-MOGþ in this cohort. They represented 28.7% (25/87) of patients who tested negative for anti-AQP4þ. Sixty-four per cent (16/25) of anti-MOGþ patients were men and had a relapsing course. Patients with recurrent optic neuritis and those with a single attack of acute longitudinally extensive transverse myelitis were the most common phenotypes. Conclusion: Relapsing optic neuritis was the most common phenotype, contrasting with a lower risk of relapses in transverse myelitis.