Antibodies to neural and non-neural autoantig… [J Neuroimmunol. 2014] – PubMed – NCBI.
Antibodies to neural and non-neural autoantigens in Japanese patients with CNS demyelinating disorders.
Author information
- 1Department of Neurology, Kitano Hospital Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka 530-8480, Japan. Electronic address: watanabe-kyu@umin.ac.jp.
- 2Department of Neurology, Kitano Hospital Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka 530-8480, Japan; Department of Community Network and Collaborative Medicine, Kyoto University Hospital, 54 Kawaharacho Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address: takakon78@hotmail.com.
- 3Department of Neurology, Kitano Hospital Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka 530-8480, Japan. Electronic address: murakata.kenji@c2.kepco.co.jp.
- 4Department of Neurology, Tenri Hospital, 200 Mishimacho, Tenri, Nara 632-8552, Japan. Electronic address: gohach65@yahoo.co.jp.
- 5Department of Neurology, Kitano Hospital Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka 530-8480, Japan. Electronic address: yokosbt7645@yahoo.co.jp.
- 6Department of Neurology, Tohoku University School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai, Miyagi 980-8574, Japan. Electronic address: t-toshiyuki@mta.biglobe.ne.jp.
- 7Department of Neurology, Saitama Medical Center, 1981 Kamoda, Kawagoe, Saitama 350-8550, Japan. Electronic address: drno@saitama-med.ac.jp.
- 8Department of Neurology, Kitano Hospital Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka 530-8480, Japan. Electronic address: smatsu@kitano-hp.or.jp.
Abstract
Anti-aquaporin 4 (AQP4) antibodies (Abs) are essential in neuromyelitis optica spectrum disorders (NMOSD), but the relationship between CNS demyelinating disorders (CNSDD) and other neural Abs remains unclear. Here we screened anti-neural Abs in the sera of 70 Japanese CNSDD patients. While two had only demyelinating events among three anti-N-methyl-d-aspartate receptor (NMDAR) Ab-positive subjects, the other subject who also had anti-AQP4 Abs experienced episodes of anti-NMDAR encephalitis and of NMOSD. Major lesions in the three anti-contactin-associated protein 2 Ab-positive subjects were infratentorial, including one co-carrying anti-AQP4 Abs. Thus, autoantibodies can be clinically silent, but multiple autoantibodies may participate in the pathogenesis.
Copyright © 2014 Elsevier B.V. All rights reserved.
KEYWORDS:
Aquaporin 4; Autoantibodies; CNS demyelinating disorders; Contactin-associated protein 2; Multiple sclerosis; Neuromyelitis optica
- PMID:
- 25027061
- [PubMed – as supplied by publisher]