There is a complex, diverse array of “preceding environmental events” and perhaps unconnected immune-related events which are often associated with the period before patients are diagnosed with NMO. In this review we discuss in detail how the different isoform structures of AQP4 in different membrane locales and in different cell types might be related to pathology. Changes in AQP4 expression in CNS and non-CNS tissue can be regulated by inflammatory mediators induced during and following infection or by underlying autoimmunity and can result in the induction of AQP4-specific lymphocytes and ensuing pathogenesis.
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- NMO FAQsAnswers to some of the most frequently asked questions about NMO, featuring video interviews with leading scientists.
- NMO & Multiple Sclerosis: Did You Know?MS and NMO are treated in different ways and early detection and treatment help ensure best outcomes.
- DiagnosisThe release of new diagnostic criteria for NMO by the International Panel for Neuromyelitis Optica Diagnosis (IPND).
- Recommended ReadingSuggested resources to read from past NMO Patient Day conferences.
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- Approved TherapeuticsAfter more than 100 years with no approved treatment, today there are three approved therapeutics for NMOSD.
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- ResearchBrowse through the results of over $70 million donated to basic and clinical research to solve neuromyelitis optica.
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- International Clinical ConsortiumThe ICC consists of thought leaders from over 25 countries performing translational research and medicine focused on NMO.
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- Predict | Clinical BiomarkersThe exciting science of biomarkers and big data analysis is enabling GJCF and its research partners to predict risks, relapses and personalized therapy.
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- Pioneer | Curative TherapiesApproved therapies are a great first step toward preventing relapses. GJCF is now pioneering bold new approaches to cure NMOSD once and for all.
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- 10 Steps Forward10 Steps Forward that may be useful for those newly diagnosed with NMOSD or MOGAD
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