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No strong HLA association with MOG antibody disease in the UK population

Melissa Grant-Peters, Giordani Rodrigues Dos Passos, Hing-Yuen Yeung, Anu Jacob, Saif Huda, Maria Isabel Leite, Calliope A Dendrou, Jacqueline Palace

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PMID: 33991459 PMCID: PMC8283171 DOI: 10.1002/acn3.51378


Improvements in assays for detecting serum antibodies against myelin oligodendrocyte glycoprotein (MOG) have led to the appreciation of MOG-antibody-associated disease (MOGAD) as a novel disorder. However, much remains unknown about its etiology. We performed human leukocyte antigen (HLA) analysis in 82 MOGAD patients of European ancestry in the UK population. No HLA class II associations were observed, thus questioning the mechanism of anti-MOG antibody generation. A weak protective association of HLA-C*03:04 was observed (OR = 0.26, 95% CI = 0.10-0.71, pc = 0.013), suggesting a need for continued efforts to better understand MOGAD genetics and pathophysiology.