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Reversible paraspinal muscle hyperintensity in anti-MOG antibody-associated transverse myelitis.

Neurol Neuroimmunol Neuroinflamm. 2017 Oct 27;5(1):e412. doi: 10.1212/NXI.0000000000000412. eCollection 2018 Jan.

Pandit L1, Mustafa S1, Uppoor R1, Nakashima I1, Takahashi T1, Kaneko K1.

Neuromyelitis optica spectrum disorder (NMOSD) associated with aquaporin-4 antibody (AQP4-Ab) predominantly targets the optic nerve and spinal cord and is characterized by frequent relapses and accrual of irreversible disability.1 Variations in clinical course may include an initial or predomi- nant involvement in extra spinal/optic nerve loca- tions and a benign course marked by mild attacks and minimal residual deficits.2,3 However, sponta- neous remissions are rare. We are reporting 2 patients who satisfied the 2015 criteria for NMOSD4 and had a unique disease course highlighted by periods of spontaneous remission lasting 19 and 23 years.

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