Posts tagged: analysis

MS-Related Disorders ID’d by Proteomic Pattern Analysis Last Updated: September 19, 2011. CSF proteomic pattern analysis discriminates among multiple sclerosis-related disorde Proteomic pattern analysis of cerebrospinal fluid analysis using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry distinguishes between similar multiple sclerosis-related disorders, according to a study published online Sept.

Water channel aquaporin-4 (AQP4) is expressed in astrocytes throughout brain and spinal cord. Two major AQP4 isoforms are expressed, M1 and M23, having different translation initiation sites

INTRODUCTION: The existence of antibodies to aquaporin-4 (AQP-4-ab) has identified neuromyelitis optica (NMO) and multiple sclerosis (MS) as different diseases. Although HLA-DRB1 alleles contribute to MS risk, recent studies suggest that HLA back-ground differs between patients with NMO or MS in non-Caucasians populations

Increased blood-brain barrier (BBB) disruption can be found in patients with neuromyelitis optica (NMO); however, its clinical implication and association with disability at acute attack remains obscure. The purpose of the study was to evaluate the clinical significance of BBB disruption and the subsequent cerebrospinal fluid (CSF)/serum IgG gradient in NMO.

The antibody suspension bead array technology has been shown to be highly applicable for discovery of potential biomarkers in blood derived samples [1]. For analysis in neurodegenerative disorders like multiple sclerosis (MS), cerebrospinal fluid (CSF) is another highly interesting body fluid for protein profiling efforts [2].

BACKGROUND: Interferon-β-1b (IFNβ-1b) has been used to prevent exacerbation of relapsing-remitting multiple sclerosis (RRMS) including optic-spinal multiple sclerosis (OSMS) in Japan. We encountered 2 patients with OSMS with unexpectedly severe exacerbation soon after the initiation of IFNβ-1b therapy. The experience urged us to retrospectively review the patients with RRMS who had been treated with IFNβ-1b to identify similar cases.