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Posts tagged: antibody

BBA Clin. 2015 Jan 15;3:126-34. doi: 10.1016/j.bbacli.2015.01.003. eCollection 2015. Kariya Y1, Kariya Y1, Saito T1, Nishiyama S2, Honda T3, Tanaka K4, Yoshida M5, Fujihara K2,…


Impaired regulatory function and enhanced intrathecal activation of B cells in neuromyelitis optica: distinct from multiple sclerosis. Quan C, Yu H, Qiao J, Xiao B, Zhao G, Wu Z, Li Z, Lu C. Source Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China


Anti-aquaporin-4 antibody in Chinese patients with central nervous system inflammatory demyelinating disorders. Long Y, Qiu W, Hu X, Peng F, Lu Z, Wang Y, Yang Y. Source Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, Guangdong Province, People’s Republic of China; Department of Neurology, Clinical College, The First Affiliated Hospital of Guangdong Pharmaceutical University, 19 Nonglinxia Road, Guangzhou 510080, Guangdong Province, People’s Republic of China.


J Neuroophthalmol. 2011 Dec 6


Neuromyelitis Optica: An Antibody-Mediated Disorder of the Central Nervous System Jiwon Oh and Michael Levy Department of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Pathology 509, Baltimore, MD 21287, USA Received 7 July 2011; Revised 4 October 2011; Accepted 13 October 2011 Academic Editor: Philippe Cabre Copyright ? 2012 Jiwon Oh and Michael Levy


Neuromyelitis optica in Japanese sisters.


Keywords: Neuromyelitis optica; Systemic lupus erythematosus; Systemic Sjogren’s; Myelitis; Autoantibody Abstract Objective: To identify the presence of neuromyelitis optica spectrum disorders (NMOSD) in patients with acute myelitis and suspected connective tissue disease (CTD), and to discuss the utility of this distinction in establishing a diagnostic and therapeutic plan. Methods: Seventeen patients with myelitis were identified from a single university-based rheumatology clinic and prospectively followed. Clinical data and serologic profile were used to determine the presence of neuromyelitis optica (NMO) or NMOSD according to established criteria


Multiple sclerosis: pathology and pathogenesis Monday, May 30, 2011, 17:15 – 18:15 The pathology of fulminant neuromyelitis optica with extremely high level of serum anti aquaporin 4 antibody K. Maruyama, M.


Washington, Feb 12 (ANI): Scientists have discovered a new technology to diagnose Alzheimer’s disease from blood samples long before symptoms appear. ? The new method uses synthetic molecules to seek out and identify disease-specific antibodies and could be a big help in diagnosing Parkinson’s disease and immune system-related diseases like multiple sclerosis and lupus, the researchers predict. ? “If we can find a way to detect the disease in its earliest stages – before cognitive impairment begins – we might be able to stop it in its tracks by developing new treatment strategies,” said Dr


In 1894, Eug?ne Devic (1858–1930) described a 45-year-old female hatter in whom ‘l’autopsie r?v?la l’existence d’un foyer de my?lite aigu? diffuse localis?e ? la r?gion du renflement lombaire et d’une n?vrite optique double bien marqu?e’ … the autopsy showed a focus of acute diffuse myelitis localized to the lumbar enlargement, as well as a distinct bilateral optic neuritis (Devic, 1894 ). He called the condition ‘neuromy?lite optique aig?e’


Devic’s syndrome was first described in 1870 by Sir Thomas Allbutt (what a name to have had as a kid!) who pointed out an association between myelitis and optic nerve disorder.? In 1894, Eugene Devic and his student Fernand Gault described 16 patients who had lost vision in one or both eyes and developed spastic weakness, sensory loss, and incontinence.? The other name of the condition was neuromyelitis optica (NMO). A major breakthrough came in 2004 when a specific marker NMO-IgG was found for the disorder [1].? IgG stands for immunoglobulin (a kind of antibody).


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