Brain. 2019 Jun 1;142(6):1598-1615. doi: 10.1093/brain/awz106. Cotzomi E1,2, Stathopoulos P1,2, Lee CS1,2, Ritchie AM3, Soltys JN3, Delmotte FR2, Oe T2, Sng J2, Jiang R2, Ma…
J Neuroinflammation. 2016 Sep 27;13(1):280. Jarius S1, Ruprecht K2, Kleiter I3, Borisow N4,5, Asgari N6, Pitarokoili K3, Pache F4,5, Stich O7, Beume LA7, Hümmert MW8,…
J Neuroinflammation. 2016 Sep 26;13(1):279. Abstract BACKGROUND: Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been suggested to play a role in a subset of patients…
J Neuroimmunol. 2015 Dec 15;289:8-11. doi: 10.1016/j.jneuroim.2015.10.007. Epub 2015 Oct 13. Alexopoulos H1, Kampylafka EI1, Fouka P2, Tatouli I1, Akrivou S1, Politis PK3, Moutsopoulos HM1,…
Abstract Neuromyelitis optica is an autoimmune disorder characterized by optic neuritis, transverse myelitis, and aquaporin-4 autoantibodies.
Aquaporin-4 (AQP4) is a water-selective transporter expressed in astrocytes throughout the central nervous system, as well as in kidney, lung, stomach and skeletal muscle. The two AQP4 isoforms produced by alternative spicing, M1 and M23 AQP4, form heterotetramers that assemble in cell plasma membranes in supramolecular structures called orthogonal arrays of particles (OAPs). Phenotype analysis of AQP4-null mice indicates the involvement of AQP4 in brain and spinal cord water balance, astrocyte migration, neural signal transduction and neuroinflammation.
Inflammatory lesions in the central nervous system of patients with neuromyelitis optica are characterized by infiltration of T cells and deposition of aquaporin-4-specific antibodies and complement on astrocytes at the glia limitans. Although the contribution of aquaporin-4-specific autoantibodies to the disease process has been recently elucidated, a potential role of aquaporin- 4-specific T cells in lesion formation is unresolved. To address this issue, we raised aquaporin-4-specific T cell lines in Lewis rats and characterized their pathogenic potential in the presence and absence of aquaporin-4-specific autoantibodies of neuromyelitis optica patients
Varieties of autoantibodies are known to relate to autoimmune neurological disorders as the diagnostic and therapeutic markers. Some of them affected directly to the pathomechanisms of neurological diseases
Background Neuromyelitis optica spectrum disorders (NMOSD) are severe central nervous system inflammatory demyelinating disorders (CNS IDD) characterized by monophasic or relapsing, longitudinally extensive transverse myelitis (LETM) and/or optic neuritis (ON). A significant proportion of NMOSD patients are seropositive for aquaporin-4 (AQP4) autoantibodies