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Posts tagged: clinical

Distinct lesion morphology at 7-T MRI differentiates neuromyelitis optica from multiple sclerosis. Sinnecker T, Dörr J, Pfueller CF, Harms L, Ruprecht K, Jarius S, Brück W, Niendorf T, Wuerfel J, Paul F. Source From the NeuroCure Clinical Research Center (T.S., J.D., C.F.P., J.W., F.P.), Clinical and Experimental Multiple Sclerosis Research Center (J.D., C.F.P., L.H., K.R., F.P.), and Department of Neurology (L.H., K.R.), Charité-Universitaetsmedizin Berlin, Berlin; Division of Molecular Neuroimmunology, Department of Neurology (S.J.), University of Heidelberg, Heidelberg; Department of Neuropathology (W.B.), University Medical Center Göttingen, Göttingen; Berlin Ultrahigh Field Facility (T.N., J.W.), Max Delbrueck Center for Molecular Medicine, Berlin; Institute of Neuroradiology (J.W.), University of Luebeck, Luebeck; and Experimental and Clinical Research Center (T.N., F.P.), Charité-Universitaetsmedizin Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, Germany


Keywords:Devic’s syndrome;neuromyelitis optica;plasma exchange;apheresis;steroid-refractory;MRI Abstract Neuromyelitis optica (NMO) is a severe inflammatory demyelinating disease of the central nervous system with exacerbations involving the optic nerves, spinal cord, or both. This study explores the utility of maintenance plasma exchange (mTPE) as a therapy in patients with relapsing, corticosteroid-refractory, NMO. This retrospective case series presents data on patients who were diagnosed with NMO using currently accepted criteria


Variable results after rituximab in neuromyelitis optica. Lindsey JW, Meulmester KM, Brod SA, Nelson F, Wolinsky JS. Abstract Our objective was to assess the efficacy of rituximab (RTX) in neuromyelitis optica (NMO)


Painful Tonic Spasm in Neuromyelitis Optica Incidence, Diagnostic Utility, and Clinical Characteristics Sung-Min Kim, MD; Min Jin Go, MS; Jung-Joon Sung, MD, PhD; Kyung Seok Park, MD, PhD; Kwang-Woo Lee, MD, PhD Arch Neurol.


Research Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients.


Neuromyelitis Optica: An Antibody-Mediated Disorder of the Central Nervous System Jiwon Oh and Michael Levy Department of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Pathology 509, Baltimore, MD 21287, USA Received 7 July 2011; Revised 4 October 2011; Accepted 13 October 2011 Academic Editor: Philippe Cabre Copyright ? 2012 Jiwon Oh and Michael Levy


Sexual dysfunction in patients with neurologic disorders ? Contributors Jasvinder Chawla MD MBA , author. Dr. Chawla of Loyola University Medical Center and Hines VA Hospital has no relevant financial relationships to disclose


Case Reports in Medicine Volume 2011 (2011), Article ID 393568, 4 pages doi:10.1155/2011/393568 Case Report Neuromyelitis Optica Spectrum Disease with Positive Autoimmune Indices: A Case Report and Review of the Literature M.


A Benign Form of Neuromyelitis Optica Does It Exist? Nicolas Collongues, MD; Philippe Cabre, MD, PhD; Romain Marignier, MD; H?l?ne Z?phir, MD; Caroline Papeix, MD; Bertrand Audoin, MD, PhD; Christine Lebrun-Frenay, MD; Jean Pelletier, MD, PhD; Bertrand Fontaine, MD, PhD; Patrick Vermersch, MD, PhD; Christian Confavreux, MD, PhD; J?r?me de Seze, MD, PhD; Group Members for NOMADMUS and CF-SEP Arch Neurol. ?2011;68(7):918-924


Keywords: diffusion tensor imaging; cervical spinal cord; neuromyelitis optica Abstract Purpose: To investigate whether quantitative MRI measures of cervical spinal cord white matter (WM) using diffusion tensor imaging (DTI) in neuromyelitis optica (NMO) differed from controls and correlated with clinical disability. Materials and Methods: Ten referred patients and 12 healthy volunteers were imaged on a 3 Tesla scanner and patients were clinically assessed on the Expanded Disability Status Scale (EDSS)


Dujmovic I, Mader S, Schanda K, Deisenhammer F, Stojsavljevic N, Kostic J, Berger T, Drulovic J, Reindl M? Temporal dynamics of cerebrospinal fluid anti-aquaporin-4 antibodies in patients with neuromyelitis optica spectrum disorders. [JOURNAL ARTICLE] J Neuroimmunol 2011?Feb?10. Neuromyelitis optica spectrum disorders (NMOSD) are associated with anti-aquaporin-4 autoantibodies (AQP4-IgG).


Abstract Neuromyelitis Optica (NMO) is a rare neuroinflammatory disorder with limited epidemiological data. Antibodies against aquaporin-4 (Aq4ab) are reported to be highly specific for NMO and NMO spectrum disorders (NMO-SD).


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