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Posts tagged: disease

Clinical Usefulness of Cell-based Indirect Immunofluorescence Assay for the Detection of Aquaporin-4 Antibodies in Neuromyelitis Optica Spectrum Disorder Eun-suk Kang, M.D.,1 Ju-Hong Min, M.D.,2 Kwang Ho Lee, M.D.,2 and Byoung Joon Kim, M.D.2 Author information ? Article notes ? Copyright and License information ? Go to: Abstract. Background The presence of antibodies to aquaporin-4 (AQP4) has been identified as a key characteristic of neuromyelitis optica spectrum disorder (NMOSD), an autoimmune inflammatory demyelinating central nervous system (CNS) disorder. We evaluated the performance of a cell-based indirect immunofluorescence assay (CIIFA) for detecting AQP4 antibodies using antigen prepared with a recombinant AQP4 peptide transfection technique and assessed the usefulness of CIIFA for diagnosis of NMOSD in routine clinical practice.


Atypical presentations of neuromyelitis optica Douglas SatoI, II; Kazuo FujiharaIII IDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan IIDepartment of Neurology, Faculty of Medicine – University of São Paulo, São Paulo SP, Brazil IIIDepartment of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine, Sendai, Japan Neuromyelitis optica (NMO) or Devic’s disease is an inflammatory disease of central nervous system classically characterized by acute, severe episodes of optic neuritis (ON) and longitudinally extensive transverse myelitis (TM)1. The article published in 1894 by Dr Eugène Devic was based on a 45-years old female patient presenting with bilateral ON followed by TM and she deceased about a month after the monophasic opticomyelitis2.


Diagnostic utility of NMO/AQP4-IgG in evaluating CNS inflammatory disease in Thai patients. Apiwattanakul M, Asawavichienjinda T, Pulkes T, Tantirittisak T, Hemachudha T, Horta ES, Jenkins SM, Pittock SJ. Source Department of Neurology, Prasat Neurological Institute, Bangkok, Thailand


Neuromyelitis optica in a patient with pemphigus foliaceus. Salazar R, Cerghet M, Farhat E, Lim HW


Growth promoting substance in human mesenchymal stem cells spurs restoration of nerves Published on May 21, 2012 at 10:24 AM A substance in human mesenchymal stem cells that promotes growth appears to spur restoration of nerves and their function in rodent models of multiple sclerosis (MS), researchers at Case Western Reserve University School of Medicine have found.


By GREG ALLMAIN Federal Way Mirror reporter April 4, 2012 · 10:46 AM With National Multiple Sclerosis (MS) Month having just ended in March, and the MS Walk coming up in Tacoma on April 14-15, there’s one Federal Way woman who is well acquainted with the disease. Deanna Kirkpatrick, 44, was diagnosed with the debilitating condition six years ago


WHILE HER COLLEAGUES ARE COUNTING DOWN THE DAYS, Rebecca Alves is one kindergarten teacher dreading the end of the school year. She suffers from a rare autoimmune disorder called Devic’s disease and has been told by her insurer that on July 1 it will stop paying for the $12,000-a-month infusions she’s been taking for seven years.


Brain Lesions May Serve as Diagnostic Criteria for Neuromyelitis Optica 2011;19(8):13. A majority of patients with neuromyelitis optica also experience disease-specific brain lesions that could help distinguish neuromyelitis optica from multiple sclerosis. MONTREAL—Imaging studies of patients with neuromyelitis optica (NMO)–spectrum disorders reveal that effects of the aquaporin-4 (AQP4) autoantibody, a marker of the disease, may extend beyond the spinal cord and optic nerve, according to researchers


Researchers at National Jewish Health have discovered a type of cell that may contribute to autoimmune disease. The findings also suggest why diseases such as lupus, multiple sclerosis and rheumatoid arthritis strike women more frequently than men


Variable results after rituximab in neuromyelitis optica. Lindsey JW, Meulmester KM, Brod SA, Nelson F, Wolinsky JS. Abstract Our objective was to assess the efficacy of rituximab (RTX) in neuromyelitis optica (NMO)


Anti-Aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Tradtrantip L , Zhang H , Saadoun S , Phuan PW , Lam C , Papadopoulos MC , Bennett JL , Verkman AS . Source Departments of Medicine and Physiology, University of California, San Francisco, CA


Beneficial Plasma Exchange Response in Central Nervous System Inflammatory Demyelination Setty M.


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