Posts tagged: extensive

Atypical presentations of neuromyelitis optica Douglas SatoI, II; Kazuo FujiharaIII IDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan IIDepartment of Neurology, Faculty of Medicine – University of São Paulo, São Paulo SP, Brazil IIIDepartment of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine, Sendai, Japan Neuromyelitis optica (NMO) or Devic’s disease is an inflammatory disease of central nervous system classically characterized by acute, severe episodes of optic neuritis (ON) and longitudinally extensive transverse myelitis (TM)1. The article published in 1894 by Dr Eugène Devic was based on a 45-years old female patient presenting with bilateral ON followed by TM and she deceased about a month after the monophasic opticomyelitis2.

Cerebrospinal fluid B-cell expansion in longitudinally extensive transverse myelitis associated with neuromyelitis optica immunoglobulin G. Dale RC, Tantsis E, Merheb V, Brilot F. Source Neuroimmunology Group, Institute of Neuroscience and Muscle Research, The Children’s Hospital at Westmead, University of Sydney, Sydney, NSW, Australia

Analysis of 103 Hungarian patients with neuromyelitis optica spectrum disease M. Banati, E. Koszegi, P

We retrospectively analyzed and compared patterns of anti-aquaporin-4 (AQP4) immunoreactivity of autopsied brains of 2 patients with classical multiple sclerosis (MS) and 2 patients with neuromyelitis optica (NMO). Serological examination for NMO-IgG was not performed in all the cases. We confirmed that the expression of AQP4 is strongly inhibited in demyelinating lesions of NMO, accompanied by the loss of grial fibrillary acidic protein (GFAP) expression

We report a case of neuromyelitis optica (NMO) with an unusual pattern of remyelination in the spinal cord. A Japanese woman complained of pain and numbness in the left thumb at the age of 36 years

A major advance over the past decade in the nosology of CNS inflammatory demyelinating diseases has been the distinction between classic MS (CMS) and neuromyelitis optica (NMO). Japanese investigators were first to recognize the optic-spinal form of MS (OSMS) in which, like NMO, clinical attacks of transverse myelitis and optic neuritis predominate.

OBJECTIVE: To investigate the differential diagnostic value of NMO-IgG for neuromyelitis optica (NMO) versus multiple sclerosis (MS) and to analyze its possible clinical features related to NMO-IgG. METHODS: Forty-one NMO patients and 44 MS patients in acute phase and 40 healthy controls were investigated. Serum NMO-IgG was tested by indirect immunofluorescence assay.

Abstract: Neuromyelitis optica (NMO), or Devic disease, has been distinguished from multiple sclerosis (MS) by the presence of optic neuritis that is usually bilateral, simultaneous, and often severe, myelopathic findings accompanied by longitudinally extensive spinal cord imaging abnormalities, no brain imaging abnormalities typical of MS, and often rapid progression to debility and even death. Researchers at the Mayo Clinic have identified an immunoglobulin marker of NMO (the NMO antibody) that binds selectively to the aquaphorin-4 water channel and may play a causative role