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Original Article Neuromyelitis optica IgG does not alter aquaporin-4 water permeability, plasma membrane M1/M23 isoform content, or supramolecular assembly Andrea Rossi1,2, Julien Ratelade1,2, Marios C. Papadopoulos3, Jeffrey L.


Impaired regulatory function and enhanced intrathecal activation of B cells in neuromyelitis optica: distinct from multiple sclerosis. Quan C, Yu H, Qiao J, Xiao B, Zhao G, Wu Z, Li Z, Lu C. Source Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China


Autoimmune diseases Monday, April 02, 2012, 17:30 – 19:00 Autologous haematopoietic stem cell transplantation in aggressive forms of neuromyelitis optica (NMO) and NMO spectrum disorders Raffaella Greco, Lucia Moiola, Paolo Rossi, Marta Radaelli, Daniela Ungaro, Massimo Bernardi, Consuelo Corti, Jacopo Peccatori, Attilio Bondanza, Maria Teresa Lupo Stanghellini, Giancarlo Comi, Fabio Ciceri (Milan, IT) ——————————————————————————– Background.


Neuromyelitis optica.


Abstract Neuromyelitis optica is an autoimmune disorder characterized by optic neuritis, transverse myelitis, and aquaporin-4 autoantibodies.


Treatment of neuromyelitis optica: an evidence based review.


Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that predominantly affects the optic nerves and spinal cord. Recombinant antibodies (rAbs) generated from clonally expanded plasma cells in an NMO patient are specific to AQP4 and pathogenic. We screened phage-displayed peptide libraries with these rAbs, and identified 14 high affinity linear and conformational peptides


OBJECTIVE: To investigate the clinical relevance of memory Th17 cells in patients with neuromyelitis optica (NMO) or multiple sclerosis (MS). PATIENTS AND METHODS: The proportion of peripheral memory Th17 cells was determined by flow cytometry. Sera IL-17A and IL-23 levels were detected by ELISA kits


The aquaporin-4 (AQP4) water channel antibody is used in the diagnosis of neuromyelitis optica (NMO) due to its high sensitivity and high specificity. However, some patients are reported to have neither optic neuritis nor myelitis despite being positive for the AQP4-autoantibody (AQP4-Ab). Therefore, recent reports suggest that such patients should be diagnosed as having ‘AQP4-autoimmune syndrome’.


OBJECTIVE: The purpose of this study was to explore brain MRI findings in neuromyelitis optica (NMO) and to investigate specific brain lesions with respect to the localization of aquaporin-4 (AQP-4). MATERIALS AND METHODS: Forty admitted patients (36 women) who satisfied the 2006 criteria of Wingerchuk et al. for NMO were included in this study


BACKGROUND: Antibodies targeting membrane proteins play an important role in various autoimmune diseases of the nervous system.


Objective: To determine anti-AQP4 antibody status in Thai patients with demyelinating diseases. Methods: Blood samples of patients visiting MS clinic at Siriraj Hospital, Thailand were collected and sent to Tohoku University for testing anti-AQP4 antibodies using AQP4-transfected cell-based assay. Diagnosis was as follows