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Posts tagged: mri

Human Umbilical Cord Mesenchymal Stem Cell Therapy on Neuromyelitis Optica. Curr Neurovasc Res


Human Umbilical Cord Mesenchymal Stem Cell Therapy on Neuromyelitis Optica. Lu Z, Ye D, Qian L, Wu J, Zhu L, Shao Y, Liu Z, Zhang X, Wang Z, Xu Y


Distinct lesion morphology at 7-T MRI differentiates neuromyelitis optica from multiple sclerosis. Sinnecker T, Dörr J, Pfueller CF, Harms L, Ruprecht K, Jarius S, Brück W, Niendorf T, Wuerfel J, Paul F. Source From the NeuroCure Clinical Research Center (T.S., J.D., C.F.P., J.W., F.P.), Clinical and Experimental Multiple Sclerosis Research Center (J.D., C.F.P., L.H., K.R., F.P.), and Department of Neurology (L.H., K.R.), Charité-Universitaetsmedizin Berlin, Berlin; Division of Molecular Neuroimmunology, Department of Neurology (S.J.), University of Heidelberg, Heidelberg; Department of Neuropathology (W.B.), University Medical Center Göttingen, Göttingen; Berlin Ultrahigh Field Facility (T.N., J.W.), Max Delbrueck Center for Molecular Medicine, Berlin; Institute of Neuroradiology (J.W.), University of Luebeck, Luebeck; and Experimental and Clinical Research Center (T.N., F.P.), Charité-Universitaetsmedizin Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, Germany


Diffuse and heterogeneous T2-hyperintense lesions in the splenium are characteristic of neuromyelitis optica.


Atypical presentations of neuromyelitis optica Douglas SatoI, II; Kazuo FujiharaIII IDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan IIDepartment of Neurology, Faculty of Medicine – University of São Paulo, São Paulo SP, Brazil IIIDepartment of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine, Sendai, Japan Neuromyelitis optica (NMO) or Devic’s disease is an inflammatory disease of central nervous system classically characterized by acute, severe episodes of optic neuritis (ON) and longitudinally extensive transverse myelitis (TM)1. The article published in 1894 by Dr Eugène Devic was based on a 45-years old female patient presenting with bilateral ON followed by TM and she deceased about a month after the monophasic opticomyelitis2.


J Child Neurol. 2012 Jul 25.


Clinical Study Brain MRI abnormalities in Brazilian patients with neuromyelitis optica Cíntia Elias Piresa, b, , , Christianne Martins Correa da Silvaa, Fernanda Cristina Rueda Lopesa, b, Fabiola Rachid Malfetanoa, Valéria C.S.R. Pereiraa, Tadeu Kubob, Paulo R.V. Bahiaa, Soniza Vieira Alves-Leona, Emerson L.


Rinsho Shinkeigaku. 2012 Jan;52(1):19-24.


Clinical features of neuromyelitis optica in a large Japanese cohort: comparison between phenotypes. J Neurol Neurosurg Psychiatry


The focus of this paper is to summarize the current knowledge on visual pathway damage in neuromyelitis optica (NMO) assessed by magnetic resonance imaging (MRI) and optical coherence tomography (OCT).


Neuromyelitis optica (NMO) is an inflammatory demyelinating disorder characterized by optic neuritis and acute myelitis. A parainfectious pathogenesis may play a partial role in the development of this disorder.


OBJECTIVE: To investigate the feature brain damage and clinical manifestations in neuromyelitis optica (NMO) patients; To investigate the relationship between serum NMO-IgG antibody and NMO brain damage. METHODS: Clinical data of 37 NMO patients and their head and spinal cord MRI by 1.5T superconducting MR scanner, were analyzed; serum NMO-IgG antibody were measured by immunofluorescence. RESULTS: 17 cases were found to have abnormal signals on MRI, which were mainly in the white matter, pons, medulla, ventricle, aqueduct, and around the corpus callosum; According to pathological changes, brain damage can be divided into scattered irregularity (13 cases), fusion (3 cases), multiple sclerosis-like (1 case), with scattered irregularity more common, 5 cases had clinical manifestations of brain damage: somnolence, vomiting, diplopia, visual rotation, 11 cases patients with brainstem damage show positive serum NMO-IgG antibodies


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