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Posts tagged: optic

Clinical Usefulness of Cell-based Indirect Immunofluorescence Assay for the Detection of Aquaporin-4 Antibodies in Neuromyelitis Optica Spectrum Disorder Eun-suk Kang, M.D.,1 Ju-Hong Min, M.D.,2 Kwang Ho Lee, M.D.,2 and Byoung Joon Kim, M.D.2 Author information ? Article notes ? Copyright and License information ? Go to: Abstract. Background The presence of antibodies to aquaporin-4 (AQP4) has been identified as a key characteristic of neuromyelitis optica spectrum disorder (NMOSD), an autoimmune inflammatory demyelinating central nervous system (CNS) disorder. We evaluated the performance of a cell-based indirect immunofluorescence assay (CIIFA) for detecting AQP4 antibodies using antigen prepared with a recombinant AQP4 peptide transfection technique and assessed the usefulness of CIIFA for diagnosis of NMOSD in routine clinical practice.


Treatment of optic neuritis by plasma exchange (add-on) in neuromyelitis optica.


Neuromyelitis optica in a patient with pemphigus foliaceus. Salazar R, Cerghet M, Farhat E, Lim HW


Rinsho Shinkeigaku. 2012 Jan;52(1):19-24.


Neuromyelitis optica in Japanese sisters.


In 1894, Eug?ne Devic (1858–1930) described a 45-year-old female hatter in whom ‘l’autopsie r?v?la l’existence d’un foyer de my?lite aigu? diffuse localis?e ? la r?gion du renflement lombaire et d’une n?vrite optique double bien marqu?e’ … the autopsy showed a focus of acute diffuse myelitis localized to the lumbar enlargement, as well as a distinct bilateral optic neuritis (Devic, 1894 ). He called the condition ‘neuromy?lite optique aig?e’


Analysis of 103 Hungarian patients with neuromyelitis optica spectrum disease M. Banati, E. Koszegi, P


Neuromyelitis optica (NMO) is an inflammatory demyelinating disorder characterized by optic neuritis and acute myelitis. A parainfectious pathogenesis may play a partial role in the development of this disorder.


Objectives: the aim of our study was to investigate whether the presence of IgG-NMO antibody is associated with a different pattern of response at visual evoked potentials (VEPs) in patients affected by neuromyelites optica spectrum of disorders (NMOsd) with optic neuritis (ON). Methods: we retrospectively studied clinical, immunological and neurophysiological data from 28 patients affected by NMOsd who presented at least one optic neuritis (16 patients bilateral and 12 unilateral).


Background: Neuromyelitis optica (NMO) is a human inflammatory/demyelinating disease of the central nervous system characterized by optic neuritis and longitudinally extensive transverse myelitis.


Background: Neuromyelitis optica (NMO) is a CNS demyelinating disease characterized by relatively selective injury to the optic nerves and spinal cord. As the prognosis and treatment differ between NMO and multiple sclerosis (MS), distinguishing these two diseases in patients presenting optic neuritis (ON) is important


Devic’s neuromyelitis optica is an inflammatory demyelinating disorder normally restricted to the optic nerves and spinal cord. Since the identification of a specific autoantibody directed against aquaporin 4, neuromyelitis optica-immunoglobulin G/aquaporin 4 antibody, neuromyelitis optica has been considered an entity distinct from multiple sclerosis


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